Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pckA (P22259) - Overview - Molecular Target Synopsis

Protein


pckA, Phosphoenolpyruvate carboxykinase (ATP)
Enzyme Classification 4.1.1.49
UniProt P22259

Also Known as PCKA_ECOLI, pckA, pck

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Monomer.

6ASI
E. COLI PHOSPHOENOLPYRUVATE CARBOXYKINASE G209S MUTANT BOUND TO METHANESULFONATE
RCSB/PDB
Inspect Structure
See all 3D Structures for pckA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: pckA is active in the following subcellular-locations: cytoplasm.
GO terms: pckA is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project pckA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pckA there are:
20 structures (22 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis