Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIP30 (P22244) - Overview - Molecular Target Synopsis

Protein


RIP30, Protein synthesis inhibitor I
Enzyme Classification 3.2.2.22
UniProt P22244

Also Known as RIP1_HORVU, RIP30

Inhibits the elongation phase of protein synthesis. It inactivates fungal ribosomes even more effectively than mammalian ribosomes and is thought to function as a constitutive antifungal agent in plants.

4FB9
STRUCTURE OF MUTANT RIP FROM BARLEY SEEDS
RCSB/PDB
Inspect Structure
See all 3D Structures for RIP30

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
281P22244-1

Sub-cellular localization


UniProt: RIP30 is active in the following subcellular-locations: cytoplasm.
GO terms: RIP30 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIP30 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RIP30 there are:
5 structures (17 chains) solved
4 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

RIP30 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (4FBC_A, 4FBC_B, 4FBC_C, 4FBC_D, 4FBH_A).

(see details)
Molecular Target 3D Synopsis