Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAD53 (P22216) - Overview - Molecular Target Synopsis

Protein


RAD53, Serine/threonine-protein kinase RAD53
Enzyme Classification 2.7.12.1
UniProt P22216

Also Known as RAD53_YEAST, RAD53, MEC2, SAD1, SPK1

Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1. Interacts with PIN4.

6C4U
ENGINEERED FHA WITH MYC-PTBD PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAD53

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
821P22216-1

Sub-cellular localization


UniProt: RAD53 is active in the following subcellular-locations: nucleus.
GO terms: RAD53 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAD53 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RAD53 there are:
27 structures (45 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAD53 has been screened with compounds ( bioactivities). (see details)