Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DMAC2L (P22027) - Overview - Molecular Target Synopsis

Protein


DMAC2L, ATP synthase subunit s, mitochondrial
UniProt P22027

Also Known as ATP5S_BOVIN, DMAC2L, ATP5S, ATPW

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Homotetramer. Associates with ATP synthase.

3E3Z
CRYSTAL STRUCTURE OF BOVINE COUPLING FACTOR B BOUND WITH PHENYLARSINE OXIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for DMAC2L

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
200P22027-1

Sub-cellular localization


UniProt: DMAC2L is active in the following subcellular-locations: mitochondrion, mitochondrion inner membrane.
GO terms: DMAC2L is active in the following subcellular-locations: mitochondrial inner membrane, proton-transporting ATP synthase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DMAC2L has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For DMAC2L there are:
4 structures (7 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis