Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pdhB (P21874) - Overview - Molecular Target Synopsis

Protein


pdhB, Pyruvate dehydrogenase E1 component subunit beta
Enzyme Classification 1.2.4.1
UniProt P21874

Also Known as ODPB_GEOSE, pdhB

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Heterodimer of an alpha and a beta chain.

3DVA
SNAPSHOTS OF CATALYSIS IN THE E1 SUBUNIT OF THE PYRUVATE DEHYDROGENASE MULTI-ENZYME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for pdhB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
325P21874-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pdhB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pdhB there are:
5 structures (20 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


pdhB has been screened with compounds ( bioactivities). (see details)