Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pdhA (P21873) - Overview - Molecular Target Synopsis

Protein


pdhA, Pyruvate dehydrogenase E1 component subunit alpha
Enzyme Classification 1.2.4.1
UniProt P21873

Also Known as ODPA_GEOSE, pdhA

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Heterodimer of an alpha and a beta chain.

3DVA
SNAPSHOTS OF CATALYSIS IN THE E1 SUBUNIT OF THE PYRUVATE DEHYDROGENASE MULTI-ENZYME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for pdhA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
369P21873-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pdhA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pdhA there are:
5 structures (20 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis