Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Ache (P21836) - Overview - Molecular Target Synopsis

Protein


Ache, Acetylcholinesterase
Enzyme Classification 3.1.1.7
UniProt P21836

Also Known as ACES_MOUSE, Ache

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers (By similarity). Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers.

6FSD
MUS MUSCULUS ACETYLCHOLINESTERASE IN COMPLEX WITH 2-(4-BIPHENYLYLOXY)- N-[3-(1-PIPERIDINYL)PROPYL]-ACETAMIDE HYDROCHLORIDE (10)
RCSB/PDB
Inspect Structure
See all 3D Structures for Ache

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
614P21836-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Ache has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Ache was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For Ache there are:
87 structures (183 chains) solved
83 are solved in complex with at least one small molecule ligand
7 are solved with an approved drug

Ache is solved in complex with the approved drug(s):

SCK/SUXAMETHONIUM (2HA2_A, 2HA2_B, 2HA6_A, 2HA6_B),
DME/DECAMETHONIUM (1MAA_A, 1MAA_B, 1MAA_C, 1MAA_D, 2XUD_A),
CVI/HEXAMETHYL PARAROSANILINE (5OV9_A, 5OV9_B),
ACH/ACETYLCHOLINE (2HA4_A, 2HA4_B),
GMN/GALLAMINE (1N5M_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Ache has been screened with 505 compounds (858 bioactivities), 129 compounds have bioactivities that show binding affinity of <= 500nM (198 bioactivities). (see details)