Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SAT1 (P21673) - Overview - Molecular Target Synopsis

Protein


SAT1, Diamine acetyltransferase 1
Enzyme Classification 2.3.1.57
UniProt P21673

Also Known as SAT1_HUMAN, SAT1, SAT

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Homodimer.

2JEV
CRYSTAL STRUCTURE OF HUMAN SPERMINE,SPERMIDINE ACETYLTRANSFERASE IN COMPLEX WITH A BISUBSTRATE ANALOG (N1- ACETYLSPERMINE-S-COA).
RCSB/PDB
Inspect Structure
See all 3D Structures for SAT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SAT1 is active in the following subcellular-locations: cytoplasm.
GO terms: SAT1 is active in the following subcellular-locations: cytosol, intracellular.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SAT1 has gain in 1 cell-lines, loss in 48 cell-lines and no signal in 956 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_8, SK_MEL_2, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SU-DHL-1, NCI-H1734, Okajima

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHEK, A549

(see details)

3D Structures


For SAT1 there are:
10 structures (18 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SAT1 has been screened with 34 compounds (55 bioactivities). (see details)