Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SYT1 (P21579) - Overview - Molecular Target Synopsis

Protein


SYT1, Synaptotagmin-1
UniProt P21579

Also Known as SYT1_HUMAN, SYT1, SVP65, SYT

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). Homotetramer (Probable). Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with PRRT2.

6G5F
18 RESIDUE FRAGMENT OF
SYNAPTOTAGMIN-1
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE B MUTANT E1191M/S1199Y IN COMPLEX WITH HUMAN SYNAPTOTAGMIN 1
RCSB/PDB
Inspect Structure
See all 3D Structures for SYT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project SYT1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H209, MDST8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, MCF-7, SK-N-SH_RA

(see details)

3D Structures


For SYT1 there are:
34 structures (50 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SYT1 has been screened with compounds ( bioactivities). (see details)