Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Abcb1a (P21447) - Overview - Molecular Target Synopsis

Protein


Abcb1a, Multidrug resistance protein 1A
Enzyme Classification 7.6.2.2
UniProt P21447

Also Known as MDR1A_MOUSE, Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Interacts with PSMB5.

6Q81
STRUCTURE OF P-GLYCOPROTEIN(ABCB1) IN THE POST-HYDROLYTIC STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for Abcb1a

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1276P21447-1

Sub-cellular localization


UniProt: Abcb1a is active in the following subcellular-locations: cell membrane.
GO terms: Abcb1a is active in the following subcellular-locations: apical part of cell, apical plasma membrane, brush border membrane, cell surface, integral component of membrane, intercellular canaliculus, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Abcb1a has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Abcb1a there are:
23 structures (34 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Abcb1a has been screened with 209 compounds (494 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (14 bioactivities). (see details)