Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM3 (P21266) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3GTU_D Glutathione S-transferase Mu 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 62.6 29.4 Yes No
2 empty 1.95 73.4 21.9 No No
3 empty 1.79 67.8 20.3 No No
4 empty 2.5 57.3 22.9 No No
5 empty 2.14 68.6 16.4 No No
6 empty 2.46 66.9 11.1 No No
7 empty 1.67 57.9 16.9 No No
8 empty 2.33 62.2 15.8 No No
9 empty 2.01 62 13.5 No No
10 empty 1.65 56.3 17.8 No No
3GTU_B Glutathione S-transferase Mu 3 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 71.9 23.4 Yes No
2 empty 2.09 60.8 29.5 No No
3 empty 1.81 67.8 19.7 No No
4 empty 1.93 59.3 19.6 No No
5 empty 2.18 68.9 13.5 No No
6 empty 2.4 66.3 12.3 No No
7 empty 1.86 57.3 15.4 No No
8 empty 2.3 62.5 14.9 No No
9 empty 2.09 62.9 13 No No
10 empty 2.03 64.6 11.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3GTU_B (17612) Glutathione S-transferase Mu 3 GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain 2.8Å Yes Yes
3GTU_D (32908) Glutathione S-transferase Mu 3 Thioredoxin fold, Thioredoxin-like, Glutathione S-transferase (GST) N-terminal domain 2.8Å No No
3GTU_B (32906) Glutathione S-transferase Mu 3 Thioredoxin fold, Thioredoxin-like, Glutathione S-transferase (GST) N-terminal domain 2.8Å No No
3GTU_D (17614) Glutathione S-transferase Mu 3 GST C-terminal domain-like, GST C-terminal domain-like, Glutathione S-transferase (GST) C-terminal domain 2.8Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


GSTM3 is involved in 5 interactions in the network.


Druggability
Overall Druggability Percentile: 64.88
Druggability for Cancer Therapeutics: 57.53
Druggability for Other Therapeutics: 75.68
Cancer-Associated
Cancer-associated percentile : 41.32
Network Articulation Point
Is GSTM3 critical for communication in the network?


Detailed Graph Legend:Help