Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM3 (P21266) - Overview - Molecular Target Synopsis

Protein


GSTM3, Glutathione S-transferase Mu 3
Enzyme Classification 2.5.1.18
UniProt P21266

Also Known as GSTM3_HUMAN, GSTM3, GST5

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. Homodimer.

3GTU
LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTM3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
225ENSG00000134202ENST00000256594, ENST00000361066, ENST00000540225ENSP00000256594, ENSP00000354357, ENSP00000444978P21266-1

Sub-cellular localization


UniProt: GSTM3 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTM3 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, intercellular bridge, nucleus, sperm fibrous sheath.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTM3 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, NCI_H460, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G112, MDA-MB-134-VI, KYSE-70

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, AG445, HSMM

(see details)

3D Structures


For GSTM3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTM3 has been screened with 2 compounds (2 bioactivities). (see details)