Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MAK (P20794) - Overview - Molecular Target Synopsis


MAK, Serine/threonine-protein kinase MAK
Enzyme Classification
UniProt P20794

Also Known as MAK_HUMAN, MAK

Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Interacts with RP1 (By similarity). Interacts with AR and CDK20. Found in a complex containing MAK, AR and NCOA3. Interacts with FZR1 (via WD repeats).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MAK is active in the following subcellular-locations: cell projection, centrosome, cilium, cytoplasm, cytoskeleton, microtubule organizing center, midbody, nucleus, photoreceptor inner segment, photoreceptor outer segment, spindle.
GO terms: MAK is active in the following subcellular-locations: axoneme, centrosome, cilium, cytoplasm, midbody, mitotic spindle, motile cilium, nucleus, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MAK has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SN12C, OVCAR_8, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO-704, NCI-H82, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

MAK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H1650, SKGT4. (see details)

3D Structures

At greater than 35% identity similarity to MAK there are:
173 structures (250 chains) solved
157 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

MAK has been screened with 85 compounds (91 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)