MAK (P20794) - Overview - Molecular Target Synopsis
MAK, Serine/threonine-protein kinase MAK
Enzyme Classification 220.127.116.11
Also Known as MAK_HUMAN, MAK
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Interacts with RP1 (By similarity). Interacts with AR and CDK20. Found in a complex containing MAK, AR and NCOA3. Interacts with FZR1 (via WD repeats).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|623||ENSG00000111837||ENST00000474039, ENST00000313243, ENST00000354489||ENSP00000476067, ENSP00000313021, ENSP00000346484||P20794-1|
UniProt: MAK is active in the following subcellular-locations: cell projection, centrosome, cilium, cytoplasm, cytoskeleton, microtubule organizing center, midbody, nucleus, photoreceptor inner segment, photoreceptor outer segment, spindle.
GO terms: MAK is active in the following subcellular-locations: axoneme, centrosome, cilium, cytoplasm, midbody, mitotic spindle, motile cilium, nucleus, photoreceptor connecting cilium, photoreceptor inner segment, photoreceptor outer segment.