Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATP4A (P20648) - Overview - Molecular Target Synopsis

Protein


ATP4A, Potassium-transporting ATPase alpha chain 1
Enzyme Classification 7.2.2.19
UniProt P20648

Also Known as ATP4A_HUMAN, ATP4A

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Composed of two subunits: alpha (catalytic) and beta.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1035ENSG00000105675ENST00000262623ENSP00000262623P20648-1
38ENSG00000105675ENST00000592767ENSP00000472323

Drugs


ATP4A is targeted by Approved Drugs Dexlansoprazole, Pantoprazole Sodium, Esomeprazole, Omeprazole, Dexrabeprazole, Lansoprazole, Rabeprazole, Pantoprazole. (see details)
Dexlansoprazole
Pantoprazole Sodium
Esomeprazole
Omeprazole
Dexrabeprazole
Lansoprazole
Rabeprazole
Pantoprazole

Sub-cellular localization


UniProt: ATP4A is active in the following subcellular-locations: cell membrane.
GO terms: ATP4A is active in the following subcellular-locations: extracellular space, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATP4A has gain in 8 cell-lines, loss in 2 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, KM12, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LN-18, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to ATP4A there are:
12 structures (13 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ATP4A is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6JXK_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ATP4A has been screened with 336 compounds (493 bioactivities), 58 compounds have bioactivities that show binding affinity of <= 500nM (93 bioactivities). (see details)