Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NPR2 (P20594) - Overview - Molecular Target Synopsis

Protein


NPR2, Atrial natriuretic peptide receptor 2
Enzyme Classification 4.6.1.2
UniProt P20594

Also Known as ANPRB_HUMAN, NPR2, ANPRB

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Isoforms / Transcripts (Protein Coding)


Drugs


NPR2 is targeted by Approved Drug Nesiritide. (see details)
Nesiritide

Sub-cellular localization


UniProt: NPR2 is active in the following subcellular-locations: cell membrane.
GO terms: NPR2 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NPR2 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, HOP_92, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, Hs 675.T, HuH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

RNA Interference


NPR2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKGT4, SMOV2. (see details)

3D Structures


At greater than 35% identity similarity to NPR2 there are:
20 structures (70 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NPR2 has been screened with 38 compounds (49 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)