Molecular Target Synopsis
Overview
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Ligand Efficiency Plot
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MSH3 (P20585) - Overview - Molecular Target Synopsis

Protein


MSH3, DNA mismatch repair protein Msh3
UniProt P20585

Also Known as MSH3_HUMAN, MSH3, DUC1, DUG

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). Heterodimer consisting of MSH2-MSH3 (MutS beta) (PubMed:8942985). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1 (PubMed:11427529). Interacts with MCM9 (PubMed:26300262).

3THW
HUMAN MUTSBETA COMPLEXED WITH AN IDL OF 4 BASES (LOOP4) AND ADP
RCSB/PDB
Inspect Structure
See all 3D Structures for MSH3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1137ENSG00000113318ENST00000265081ENSP00000265081P20585-1

Sub-cellular localization


GO terms: MSH3 is active in the following subcellular-locations: membrane, mismatch repair complex, MutSbeta complex, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MSH3 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, CCRF_CEM, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NU-DUL-1, Caov-3, SR-786

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

3D Structures


For MSH3 there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis