Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB4A (P20338) - Overview - Molecular Target Synopsis

Protein


RAB4A, Ras-related protein Rab-4A
UniProt P20338

Also Known as RAB4A_HUMAN, RAB4A, RAB4

Protein transport. Probably involved in vesicular traffic. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1 (PubMed:10698684, PubMed:11786538, PubMed:11788822, PubMed:14617813, PubMed:15280022, PubMed:16034420). Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin (PubMed:17786215). Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (PubMed:20098723). Interacts with RABEP1 and RBSN (PubMed:20098723). Does not interact with HPS4.

1YU9
GPPNHP-BOUND RAB4A
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB4A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
218ENSG00000168118ENST00000366690ENSP00000355651P20338-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB4A has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, COLO205, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MS751, OCI-AML2, G112

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, NHEK, HSMM

(see details)

3D Structures


For RAB4A there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB4A has been screened with compounds ( bioactivities). (see details)