Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB3B (P20337) - Overview - Molecular Target Synopsis

Protein


RAB3B, Ras-related protein Rab-3B
UniProt P20337

Also Known as RAB3B_HUMAN, RAB3B

Protein transport. Probably involved in vesicular traffic (By similarity). Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains).

3DZ8
CRYSTAL STRUCTURE OF HUMAN RAB3B GTPASE BOUND WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB3B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
219ENSG00000169213ENST00000371655ENSP00000360718P20337-1

Sub-cellular localization


UniProt: RAB3B is active in the following subcellular-locations: cell membrane, golgi apparatus.
GO terms: RAB3B is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, cytoplasm, cytosol, dopaminergic synapse, endosome, extracellular exosome, Golgi apparatus, perinuclear region of cytoplasm, plasma membrane, secretory granule, synaptic vesicle, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB3B has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, ACHN, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, VMRC-LCD, NCI-H460

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, IMR-90, BJ

(see details)

3D Structures


For RAB3B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB3B has been screened with compounds ( bioactivities). (see details)