TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B
Also Known as
TNR1B_HUMAN, TNFRSF1B, TNFBR, TNFR2
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX.
Variants and Isoforms
UniProt: TNFRSF1B is active in the following subcellular-locations: Cell membrane, Secreted.
Mutations in Cancer
|Please click the link to see mutations reported in Cancer Gene Census|
|Please click the link to see mutations reported in ICGC|
|According to the Cosmic, TNFRSF1B has 0 reported mutations in cell lines ....|
The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic
Bamford et al (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 91,355-358.
|Please click the link to see mutations reported in MoKCa|
In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: HCT116, OVCAR8. (see details)
TNFRSF1B was reported in the following RNAI studies:
AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)
Screening and Chemistry
TNFRSF1B has been screened with 1 compounds (1 bioactivities). (see details)