Molecular Target
Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Cellline Data Matrix
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

Molecular Target Synopsis - TNFRSF1B (P20333) - Overview

Protein


TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B
UniProt P20333

Also Known as TNR1B_HUMAN, TNFRSF1B, TNFBR, TNFR2

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX.

Variants and Isoforms


P20333-1, P20333-2

Sub-cellular localization


UniProt: TNFRSF1B is active in the following subcellular-locations: Cell membrane, Secreted.



UniProt
GO terms

Mutations in Cancer


Please click the link to see mutations reported in Cancer Gene Census

Please click the link to see mutations reported in ICGC

According to the Cosmic, TNFRSF1B has 0 reported mutations in cell lines ....

The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic
Bamford et al (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 91,355-358.
Please click the link to see mutations reported in MoKCa

(see details)

Gene Expression


In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: HCT116, OVCAR8. (see details)

RNA Interference


TNFRSF1B was reported in the following RNAI studies:

AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)

3D Structures


There are 2 structures (8 chains) solved for TNFRSF1B
0 are solved in complex with at least one small molecule ligand


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TNFRSF1B has been screened with 1 compounds (1 bioactivities). (see details)