Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Cellline Data Matrix
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

TNFRSF1B (P20333) - Overview - Molecular Target Synopsis



Protein


TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B
UniProt P20333

Also Known as TNR1B_HUMAN, TNFRSF1B, TNFBR, TNFR2

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX.

3ALQ deposition date (2010-08-06)
CRYSTAL STRUCTURE OF TNF-TNFR2 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for TNFRSF1B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
461ENSG00000028137ENST00000376259ENSP00000365435P20333-1
268P20333-2
155ENSG00000028137ENST00000536782ENSP00000440425

Sequences


>ENSG00000028137,ENST00000376259,ENSP00000365435,P20333

MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA 
QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC
SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA
RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC
TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP
AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV
PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA
PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ
ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP
LGVPDAGMKP S

>P20333-2

MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA 
QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC
SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA
RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC
TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP
AEGSTGDFAL PVASLACR

>ENSG00000028137,ENST00000536782,ENSP00000440425

MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA 
QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC
SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA
RPDLS

Sub-cellular localization


UniProt: TNFRSF1B is active in the following subcellular-locations: Cell membrane, Secreted.
GO terms: TNFRSF1B is active in the following subcellular-locations: extracellular region, integral component of membrane, membrane raft, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, varicosity.



UniProt
GO terms

Mutations in Cancer


In COSMIC - Cell Lines Project there are 31 unique mutations of TNFRSF1B: p.? (4), p.R431Q (2), p.A308T (1), p.T70S (1), p.E132V (1), p.P261S (1), p.H375H (1), p.E44* (1), p.E446V (1), p.Q317P (1), p.S336T (1), p.T201T (1), p.Q225K (1), p.E446D (1), p.G153E (1), p.F258F (1), p.T439T (1), p.T111S (1), p.N115K (1), p.C110F (1), p.P91P (1), p.Q85H (1), p.P91S (1), p.L140L (1), p.H182P (1), p.S370F (1), p.S413S (1), p.R309G (1), p.L274L (1), p.G246fs*19 (1), p.T68T (1)
In COSMIC there are 45 unique mutations of TNFRSF1B: p.V214A (3), p.R431W (2), p.K56K (2), p.T222P (2), p.T203T (2), p.M196R (2), p.D306N (2), p.D257N (1), p.V385L (1), p.F258F (1), p.A213P (1), p.G442E (1), p.S58L (1), p.T222T (1), p.M405I (1), p.G146C (1), p.Q433Q (1), p.C143C (1), p.P314P (1), p.Y45F (1), p.H215Y (1), p.D409H (1), p.T84I (1), p.R141H (1), p.T49T (1), p.V159M (1), p.G457G (1), p.P261P (1), p.A342A (1), p.K142M (1), p.? (1), p.K425K (1), p.G37R (1), p.H302L (1), p.S432L (1), p.S461N (1), p.G146R (1), p.T222K (1), p.E232K (1), p.P139L (1), p.S101R (1), p.R309R (1), p.G153R (1), p.I384_C388delIVNVC (1), p.S413S (1)
Please click the link to see mutations reported in Cancer Gene Census
Please click the link to see mutations reported in ICGC
(see details)

Gene Expression


In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: COLO205, SW620. (see details)

RNA Interference


TNFRSF1B was reported in the following RNAI studies:

AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)

3D Structures


There are 2 structures (8 chains) solved for TNFRSF1B
0 are solved in complex with at least one small molecule ligand


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TNFRSF1B has been screened with 1 compounds (1 bioactivities). (see details)