Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CCNA2 (P20248) - Overview - Molecular Target Synopsis

Protein


CCNA2, Cyclin-A2
UniProt P20248

Also Known as CCNA2_HUMAN, CCNA2, CCN1, CCNA

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187).

6GVA
CDK2/CYCLIN A2 IN COMPLEX WITH PYRAZOLO[4,3-D]PYRIMIDINE INHIBITOR LGR4455
RCSB/PDB
Inspect Structure
See all 3D Structures for CCNA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
432ENSG00000145386ENST00000274026ENSP00000274026P20248-1

Sub-cellular localization


UniProt: CCNA2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CCNA2 is active in the following subcellular-locations: cyclin A2-CDK2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, female pronucleus, male pronucleus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CCNA2 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, K_562, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, LN-18, G111

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, HeLa-S3

(see details)

3D Structures


For CCNA2 there are:
91 structures (179 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CCNA2 has been screened with 3279 compounds (4147 bioactivities), 1093 compounds have bioactivities that show binding affinity of <= 500nM (1314 bioactivities). (see details)