Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ORM2 (P19652) - Overview - Molecular Target Synopsis

Protein


ORM2, Alpha-1-acid glycoprotein 2
UniProt P19652

Also Known as A1AG2_HUMAN, ORM2, AGP2

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

3APU
CRYSTAL STRUCTURE OF THE A VARIANT OF HUMAN ALPHA1-ACID GLYCOPROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ORM2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
205ENSG00000228278ENST00000412657ENSP00000407099
201ENSG00000228278ENST00000431067ENSP00000394936P19652-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project ORM2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: C3A, Hep G2, JHH-5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HepG2, SK-N-SH, NHLF

(see details)

3D Structures


For ORM2 there are:
4 structures (7 chains) solved
3 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ORM2 is solved in complex with the approved drug(s):

TP0/AMITRIPTYLINE (3APV_A, 3APV_B),
Z80/CHLORPROMAZINE (3APX_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ORM2 has been screened with 1 compounds (1 bioactivities). (see details)