Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Maob (P19643) - Overview - Molecular Target Synopsis

Protein


Maob, Amine oxidase [flavin-containing] B
Enzyme Classification 1.4.3.4
UniProt P19643

Also Known as AOFB_RAT, Maob

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
520P19643-1

Sub-cellular localization


UniProt: Maob is active in the following subcellular-locations: mitochondrion outer membrane.
GO terms: Maob is active in the following subcellular-locations: integral component of membrane, mitochondrial outer membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Maob has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Maob has been screened with 1713 compounds (2596 bioactivities), 368 compounds have bioactivities that show binding affinity of <= 500nM (529 bioactivities). (see details)