Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFE3 (P19532) - Overview - Molecular Target Synopsis

Protein


TFE3, Transcription factor E3
UniProt P19532

Also Known as TFE3_HUMAN, TFE3, BHLHE33

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. Homodimer and heterodimer; with TFEB or MITF.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
575ENSG00000068323ENST00000315869ENSP00000314129P19532-1
109ENSG00000068323ENST00000493583ENSP00000476976P19532-2

Sub-cellular localization


UniProt: TFE3 is active in the following subcellular-locations: nucleus.
GO terms: TFE3 is active in the following subcellular-locations: cytosol, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFE3 has gain in 1 cell-lines, loss in 62 cell-lines and no signal in 942 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, SNB_75, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-423, HCC366, LCLC-103H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, HeLa-S3

(see details)

3D Structures


At greater than 75% identity similarity to TFE3 there are:
5 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TFE3 has been screened with compounds ( bioactivities). (see details)