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ATP4A (P19156) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria7
Chains with at least one site assessed as druggable using the relaxed criteria9


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2XZB_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 70.2 73.3 Yes Yes
2 empty 1.94 67.6 64.5 No No
3 empty 1.07 77.1 51.8 No No
4 empty 2.35 70.4 29.2 No No
5 empty 2.08 78.3 21.4 No No
6 empty 1.9 62.4 19.4 No No
7 empty 1.76 67.9 21.2 No No
8 empty 2.32 67.2 22 No No
9 empty 2.23 66.1 22.6 No No
10 empty 2.22 67.5 25.6 No No
1IWF_A Potassium-transporting ATPase alpha chain 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 58.9 34 Yes No
2 empty 2.67 52.7 15.9 No No
3 empty 1.32 53.7 9.3 No No
4 empty 2.73 60.4 7.5 No No
5 empty 3.08 53.6 6.4 No No
4UX2_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 74.7 56.5 Yes Yes
2 empty 2.21 73.2 46.4 No No
3 empty 1.47 77.2 37.7 No No
4 empty 1.59 65.4 44.7 No No
5 empty 2.36 70.8 28.7 No No
6 empty 2.46 65.1 29.6 No No
7 empty 1.06 65 31.5 No No
8 empty .99 68.7 22.5 No No
9 empty 2.07 66.9 20.2 No No
10 empty 2.38 68.9 20 No No
2YN9_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 76.3 59.3 Yes Yes
2 empty 2.08 68.5 45.9 No No
3 empty 1.58 73.2 39.7 No No
4 empty 2.1 68.6 43.5 No No
5 empty 1.67 65.7 42.8 No No
6 empty 2.1 64 29.1 No No
7 empty 2.1 74.9 34.9 No No
8 empty 1.25 70.1 30.5 No No
9 empty 2.27 66.6 27 No No
10 empty 2.29 69.9 16.9 No No
5YLV_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 75.4 85.1 Yes Yes
2 empty 1.85 66.2 56.4 No No
3 bound 1.78 75.4 46.7 No No
4 empty 1.55 65.6 44.5 No No
5 empty 2.21 64.1 26.6 No No
6 empty 2.24 60.7 26.2 No No
7 empty 2.31 61.8 17.9 No No
8 empty 2.08 71.4 12.1 No No
9 empty 1.69 75.7 14 No No
10 empty .72 69.4 17.6 No No
5Y0B_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 73.7 70.8 Yes Yes
2 empty 1.32 74.9 40.6 Yes No
3 empty 2.31 70.1 28.7 No No
4 empty 2.09 62.8 35.2 No No
5 empty 2.35 66.8 29.9 No No
6 empty .95 63.1 37.5 No No
7 empty 2.25 75.4 27.7 No No
8 empty 1.97 69.8 23.5 No No
9 empty 2.26 64.3 27.1 No No
10 empty 2.13 65.9 26 No No
4UX1_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 70.5 58.2 Yes Yes
2 empty 2.14 74.6 57.9 No No
3 empty 1.64 76.3 36.6 No No
4 empty 2.33 69 29.4 No No
5 empty .92 64.6 27.1 No No
6 empty 1.83 67.3 26.6 No No
7 empty 2.11 63.4 24.6 No No
8 empty 2.34 68.4 17.6 No No
9 empty .83 69.2 14.4 No No
10 empty 1.93 65.7 17.4 No No
5YLU_A Potassium-transporting ATPase alpha chain 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 78.3 56.5 Yes Yes
2 empty 1.92 64.7 61.2 No No
3 bound 1.67 74 36.5 No No
4 empty 1.71 68.2 26.8 No No
5 empty 2.37 72 22.8 No No
6 empty 2.22 70.2 19.7 No No
7 empty 1.8 59.8 18.9 No No
8 empty 2.1 58.8 25.1 No No
9 empty 2.41 71 13.7 No No
10 empty 2.21 56.7 19.3 No No
1IWC_A Potassium-transporting ATPase alpha chain 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 72 9.4 Yes No
2 empty 2.39 73 7 No No
3 empty 2.14 59.4 9.4 No No
4 empty 2.59 47.9 10 No No
5 empty 2.84 50.8 8.2 No No
6 empty 3.02 57.3 7.8 No No
7 empty 2.11 64.4 6.6 No No
8 empty 1.94 67.7 5.5 No No
9 empty 2.31 68.7 0 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria7

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1IWC_A (76872) Potassium-transporting ATPase alpha chain 1 N-terminal fragment of gastric H/K-ATPase, N-terminal fragment of gastric H/K-ATPase, N-terminal fragment of gastric H/K-ATPase Yes No
1IWF_A (76873) Potassium-transporting ATPase alpha chain 1 N-terminal fragment of gastric H/K-ATPase, N-terminal fragment of gastric H/K-ATPase, N-terminal fragment of gastric H/K-ATPase Yes No
2XZB_A (3590465) Potassium-transporting ATPase alpha chain 1 Calcium ATPase transmembrane domain M, Calcium ATPase transmembrane domain M, UNMATCHED 7Å Yes Yes
2XZB_A (3590462) Potassium-transporting ATPase alpha chain 1 Calcium ATPase transmembrane domain M, Calcium ATPase transmembrane domain M, UNMATCHED 7Å No No
2XZB_A (3590463) Potassium-transporting ATPase alpha chain 1 Metal cation-transporting ATPase ATP-binding domain N, Metal cation-transporting ATPase ATP-binding domain N, UNMATCHED 7Å Yes No
2XZB_A (3590464) Potassium-transporting ATPase alpha chain 1 HAD-like, HAD-like, UNMATCHED 7Å Yes Yes
2XZB_A (3590460) Potassium-transporting ATPase alpha chain 1 UNMATCHED, UNMATCHED, UNMATCHED 2XZB 7Å No No
2XZB_A (3590459) Potassium-transporting ATPase alpha chain 1 PFAM, PFAM, PFAM Cation_ATPase_N 7Å Yes No
2XZB_A (3590461) Potassium-transporting ATPase alpha chain 1 Double-stranded beta-helix, Calcium ATPase transduction domain A, UNMATCHED 7Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score