Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ATP4A (P19156) - Overview - Molecular Target Synopsis


ATP4A, Potassium-transporting ATPase alpha chain 1
Enzyme Classification
UniProt P19156

Also Known as ATP4A_PIG, ATP4A

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Composed of two subunits: alpha (catalytic) and beta.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: ATP4A is active in the following subcellular-locations: cell membrane.
GO terms: ATP4A is active in the following subcellular-locations: integral component of membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ATP4A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For ATP4A there are:
10 structures (10 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ATP4A has been screened with 498 compounds (553 bioactivities), 71 compounds have bioactivities that show binding affinity of <= 500nM (71 bioactivities). (see details)