Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATP4A (P19156) - Overview - Molecular Target Synopsis

Protein


ATP4A, Potassium-transporting ATPase alpha chain 1
Enzyme Classification 7.2.2.19
UniProt P19156

Also Known as ATP4A_PIG, ATP4A

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Composed of two subunits: alpha (catalytic) and beta.

5YLU
CRYSTAL STRUCTURE OF THE GASTRIC PROTON PUMP COMPLEXED WITH VONOPRAZAN
RCSB/PDB
Inspect Structure
See all 3D Structures for ATP4A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1034P19156-1

Sub-cellular localization


UniProt: ATP4A is active in the following subcellular-locations: cell membrane.
GO terms: ATP4A is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATP4A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ATP4A there are:
10 structures (10 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ATP4A has been screened with 498 compounds (553 bioactivities), 71 compounds have bioactivities that show binding affinity of <= 500nM (71 bioactivities). (see details)