Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Fasn (P19096) - Overview - Molecular Target Synopsis

Protein


Fasn, Fatty acid synthase
Enzyme Classification 2.3.1.85
UniProt P19096

Also Known as FAS_MOUSE, Fasn

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Homodimer which is arranged in a head to tail fashion (By similarity). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.

5MY2
KS-MAT DI-DOMAIN OF MOUSE FAS
RCSB/PDB
Inspect Structure
See all 3D Structures for Fasn

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2504P19096-1

Sub-cellular localization


UniProt: Fasn is active in the following subcellular-locations: cytoplasm, melanosome.
GO terms: Fasn is active in the following subcellular-locations: cytoplasm, cytosol, glycogen granule, Golgi apparatus, melanosome, mitochondrion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Fasn has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Fasn there are:
2 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Fasn has been screened with 4 compounds (4 bioactivities). (see details)