Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Drd1 (P18901) - Overview - Molecular Target Synopsis

Protein


Drd1, D(1A) dopamine receptor
UniProt P18901

Also Known as DRD1_RAT, Drd1, Drd1a

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Interacts with DNAJC14 via its C-terminus (PubMed:11331877). Interacts with DRD2.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
446P18901-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Drd1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Screening and Chemistry


Drd1 has been screened with 2062 compounds (3716 bioactivities), 731 compounds have bioactivities that show binding affinity of <= 500nM (1227 bioactivities). (see details)