GABRB1 (P18505) - Overview - Molecular Target Synopsis
GABRB1, Gamma-aminobutyric acid receptor subunit beta-1
Also Known as GBRB1_HUMAN, GABRB1
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Binds UBQLN1 (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: GABRB1 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: GABRB1 is active in the following subcellular-locations: cell junction, chloride channel complex, cytoplasm, dendrite, GABA-A receptor complex, GABA-ergic synapse, integral component of plasma membrane, neuron projection, nuclear envelope, plasma membrane, postsynaptic membrane, synapse.