Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HLA-B (P18465) - Overview - Molecular Target Synopsis

Protein


HLA-B, HLA class I histocompatibility antigen, B-57 alpha chain
UniProt P18465

Also Known as 1B57_HUMAN, HLA-B, HLAB

Involved in the presentation of foreign antigens to the immune system. Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

6D2B
HLA-B*57:01 PRESENTING LSDSTARDVTW
RCSB/PDB
Inspect Structure
See all 3D Structures for HLA-B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
362P18465-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project HLA-B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, SF_539, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-24, SUP-B15, Pfeiffer

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, IMR-90

(see details)

3D Structures


For HLA-B there are:
34 structures (38 chains) solved
4 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

HLA-B is solved in complex with the approved drug(s):

1KX/ABACAVIR (3UPR_A, 3UPR_C, 3VRI_A, 3VRJ_A, 5U98_A, 5U98_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HLA-B has been screened with compounds ( bioactivities). (see details)