Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAT1 (P18440) - Overview - Molecular Target Synopsis

Protein


NAT1, Arylamine N-acetyltransferase 1
Enzyme Classification 2.3.1.5
UniProt P18440

Also Known as ARY1_HUMAN, NAT1, AAC1

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

2PQT
HUMAN N-ACETYLTRANSFERASE 1
RCSB/PDB
Inspect Structure
See all 3D Structures for NAT1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
381ENSG00000171428ENST00000520546ENSP00000429341
352ENSG00000171428ENST00000545197ENSP00000443194
290P18440-1

Sub-cellular localization


UniProt: NAT1 is active in the following subcellular-locations: cytoplasm.
GO terms: NAT1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAT1 has gain in 0 cell-lines, loss in 11 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HCC_2998, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1500, HCC2911, CaR-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

3D Structures


For NAT1 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NAT1 has been screened with 52 compounds (60 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)