Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATP4B (P18434) - Overview - Molecular Target Synopsis

Protein


ATP4B, Potassium-transporting ATPase subunit beta
UniProt P18434

Also Known as ATP4B_PIG, ATP4B

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. Composed of two subunits: alpha (catalytic) and beta.

5YLU
CRYSTAL STRUCTURE OF THE GASTRIC PROTON PUMP COMPLEXED WITH VONOPRAZAN
RCSB/PDB
Inspect Structure
See all 3D Structures for ATP4B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
290P18434-1

Sub-cellular localization


UniProt: ATP4B is active in the following subcellular-locations: cell membrane.
GO terms: ATP4B is active in the following subcellular-locations: sodium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATP4B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ATP4B there are:
8 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ATP4B has been screened with 438 compounds (496 bioactivities), 60 compounds have bioactivities that show binding affinity of <= 500nM (60 bioactivities). (see details)