Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARF4 (P18085) - Overview - Molecular Target Synopsis

Protein


ARF4, ADP-ribosylation factor 4
UniProt P18085

Also Known as ARF4_HUMAN, ARF4, ARF2

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

1Z6X
STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 4
RCSB/PDB
Inspect Structure
See all 3D Structures for ARF4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARF4 is active in the following subcellular-locations: golgi apparatus, membrane.
GO terms: ARF4 is active in the following subcellular-locations: cytoplasm, cytosol, dendritic spine, extracellular exosome, glutamatergic synapse, Golgi apparatus, membrane, plasma membrane, ruffle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARF4 has gain in 0 cell-lines, loss in 9 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SNB_75, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 578T, HCC193, Hs 38.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, IMR-90

(see details)

3D Structures


For ARF4 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARF4 has been screened with compounds ( bioactivities). (see details)