Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPC31 (P17890) - Overview - Molecular Target Synopsis

Protein


RPC31, DNA-directed RNA polymerase III subunit RPC7
UniProt P17890

Also Known as RPC7_YEAST, RPC31, ACP2, RPC8

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. C31 is involved in the formation of the initiation complex. Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

6CNF
YEAST RNA POLYMERASE III ELONGATION COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RPC31

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
251P17890-1

Sub-cellular localization


UniProt: RPC31 is active in the following subcellular-locations: nucleus.
GO terms: RPC31 is active in the following subcellular-locations: nucleoplasm, RNA polymerase III complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPC31 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPC31 there are:
15 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis