Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AMD1 (P17707) - Overview - Molecular Target Synopsis

Protein


AMD1, S-adenosylmethionine decarboxylase proenzyme
Enzyme Classification 4.1.1.50
UniProt P17707

Also Known as DCAM_HUMAN, AMD1, AMD

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Heterotetramer of two alpha and two beta chains.

3H0W
HUMAN ADOMETDC WITH 5'-DEOXY-5'-[(N-DIMETHYL)AMINO]-8-METHYL-ADENOSINE
RCSB/PDB
Inspect Structure
See all 3D Structures for AMD1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: AMD1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AMD1 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, MOLT_4, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LNCAP, SK-MEL-24, Okajima

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

3D Structures


For AMD1 there are:
25 structures (54 chains) solved
23 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AMD1 has been screened with 192 compounds (233 bioactivities), 17 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)