Molecular Target Synopsis
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Gata1 (P17679) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed7
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1GNF_A Erythroid transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 66.4 19.8 No No
2 empty 2.52 77.7 14.1 No No
3 empty 2.33 62.2 13.4 No No
4 empty 2.47 56.3 11.5 No No
5 empty 2.74 55.1 6.3 No No
6 empty 3.19 65.4 7 No No
7 empty 2.56 70.7 6.3 No No
8 empty 2.87 56.3 5.6 No No
9 empty 2.15 54.3 6.7 No No
10 empty 2.55 70.9 5.2 No No
3VEK_F Erythroid transcription factor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 61.7 42.8 Yes No
2 empty 2.3 72.8 16.9 No No
3 empty 2.67 66.8 11.1 No No
4 empty 2.05 65.9 7.2 No No
5 empty 2.62 63 7.1 No No
6 empty 2.55 67.1 7.4 No No
7 empty 2.75 56.5 6.4 No No
8 empty 1.04 54.7 6.7 No No
9 empty 2.66 57.8 5.8 No No
10 empty 2 51.5 7.4 No No
1Y0J_A Erythroid transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.64 66 20.4 No No
2 empty 2.47 72.4 10.5 No No
3 empty 2.48 77.3 8.4 No No
4 empty 2.23 63.6 7.2 No No
5 empty 2.8 62.5 5.1 No No
6 empty 2.05 75 0 No No
7 empty .84 66.7 4.8 No No
3VEK_C Erythroid transcription factor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 63.9 38.8 Yes No
2 empty 2.28 72.1 17.5 No No
3 empty 2.7 68 9.3 No No
4 empty 2.46 65.9 11 No No
5 empty 2.05 65.1 8 No No
6 empty 2.5 52.7 10.7 No No
7 empty 2.57 66.7 5.9 No No
8 empty 2.7 54.2 6.6 No No
9 empty 2.12 54.3 7.6 No No
10 empty 1.16 47.4 7 No No
3VD6_C Erythroid transcription factor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 62.9 48.1 Yes No
2 empty 2.16 64.6 11.8 No No
3 empty 2.15 72.8 10.1 No No
4 empty 2.12 66.9 7.8 No No
5 empty 2.56 64.1 6.6 No No
6 empty 2.55 61.2 9.7 No No
7 empty 2.64 59.2 6.2 No No
8 empty 1.24 56.7 6.9 No No
9 empty 2.38 65.5 4.7 No No
10 empty 3.16 100 0 Yes No
2L6Z_A Erythroid transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 59.9 20.9 No No
2 empty 1.83 69.9 6.9 No No
3 empty 3.1 71 7.1 No No
4 empty 1.73 54.7 7.6 No No
5 empty 2.96 71.1 5.1 No No
6 empty 2.02 58.3 5 No No
2L6Y_A Erythroid transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 60 19.2 No No
2 empty 2.78 68.7 9.8 No No
3 empty 2.51 68.7 5.8 No No
4 empty 2.7 57 10.3 No No
5 empty 1.94 61.8 5.3 No No
6 empty 2.39 54.1 5.3 No No
7 empty 3.64 71 4.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1GNF_A (45107) Erythroid transcription factor Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Erythroid transcription factor GATA-1 No No
1Y0J_A (122483) Erythroid transcription factor Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), Erythroid transcription factor GATA-1 No No
2L6Y_A (3580116) Erythroid transcription factor Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), UNMATCHED No No
2L6Z_A (3580119) Erythroid transcription factor Glucocorticoid receptor-like (DNA-binding domain), Glucocorticoid receptor-like (DNA-binding domain), UNMATCHED No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score