Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Gata1 (P17679) - Overview - Molecular Target Synopsis

Protein


Gata1, Erythroid transcription factor
UniProt P17679

Also Known as GATA1_MOUSE, Gata1, Gf-1

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1 (By similarity). Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with BRD3. Interacts with MED1, CCAR1 and CALCOCO1. Interacts with EP300 (By similarity). Interacts with CEBPE.

3VEK
BOTH ZN FINGERS OF GATA1 BOUND TO PALINDROMIC DNA RECOGNITION SITE, P1 CRYSTAL FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for Gata1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
413P17679-1
330P17679-2

Sub-cellular localization


UniProt: Gata1 is active in the following subcellular-locations: nucleus.
GO terms: Gata1 is active in the following subcellular-locations: nucleus, protein-DNA complex, transcription factor complex, transcriptional repressor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Gata1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Gata1 there are:
7 structures (8 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Gata1 has been screened with compounds ( bioactivities). (see details)