Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXB9 (P17482) - Overview - Molecular Target Synopsis

Protein


HOXB9, Homeobox protein Hox-B9
UniProt P17482

Also Known as HXB9_HUMAN, HOXB9, HOX2E

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
250ENSG00000170689ENST00000311177ENSP00000309439P17482-1
134ENSG00000170689ENST00000550387ENSP00000447530

Sub-cellular localization


UniProt: HOXB9 is active in the following subcellular-locations: nucleus.
GO terms: HOXB9 is active in the following subcellular-locations: mitochondrion, nucleoplasm, RNA polymerase II transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXB9 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HCT_15, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, SW 1463, SW 1417

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, A549, SK-N-SH

(see details)

3D Structures


At greater than 90% identity similarity to HOXB9 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXB9 has been screened with compounds ( bioactivities). (see details)