Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HOXB9 (P17482) - Overview - Molecular Target Synopsis


HOXB9, Homeobox protein Hox-B9
UniProt P17482

Also Known as HXB9_HUMAN, HOXB9, HOX2E

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HOXB9 is active in the following subcellular-locations: nucleus.
GO terms: HOXB9 is active in the following subcellular-locations: mitochondrion, nucleoplasm, RNA polymerase II transcription factor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HOXB9 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, HCT_15, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, SW 1463, SW 1417

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, A549, SK-N-SH

(see details)

3D Structures

At greater than 90% identity similarity to HOXB9 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

HOXB9 has been screened with compounds ( bioactivities). (see details)