Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rpsG (P17291) - Overview - Molecular Target Synopsis

Protein


rpsG, 30S ribosomal protein S7
UniProt P17291

Also Known as RS7_THET8, rpsG, rps7

One of the primary rRNA binding proteins, it binds directly to 3'-end of the 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center. Binds mRNA and the E site tRNA blocking its exit path in the ribosome. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA. Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. Binds to the C-terminus of IF3 and to the C-terminus of Era.

6CAO
STRUCTURE OF THE RIBOSOMAL DECODING COMPLEX AT AMBIENT TEMPERATURE
RCSB/PDB
Inspect Structure
See all 3D Structures for rpsG

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rpsG is active in the following subcellular-locations: small ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rpsG has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rpsG there are:
125 structures (125 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis