Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Mvk (P17256) - Overview - Molecular Target Synopsis

Protein


Mvk, Mevalonate kinase
Enzyme Classification 2.7.1.36
UniProt P17256

Also Known as KIME_RAT, Mvk

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. Homodimer.

2R42
THE BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACK INHIBITION OF MEVALONATE KINASE AND ISOPRENOID METABOLISM
RCSB/PDB
Inspect Structure
See all 3D Structures for Mvk

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
395P17256-1

Sub-cellular localization


UniProt: Mvk is active in the following subcellular-locations: cytoplasm, peroxisome.
GO terms: Mvk is active in the following subcellular-locations: cytoplasm, cytosol, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mvk has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Mvk there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Mvk has been screened with 1 compounds (1 bioactivities). (see details)