Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

glmS (P17169) - Overview - Molecular Target Synopsis

Protein


glmS, Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Enzyme Classification 2.6.1.16
UniProt P17169

Also Known as GLMS_ECOLI, glmS

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. Homodimer.

4AMV
E.COLI GLUCOSAMINE-6P SYNTHASE IN COMPLEX WITH FRUCTOSE-6P
RCSB/PDB
Inspect Structure
See all 3D Structures for glmS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
609P17169-1

Sub-cellular localization


UniProt: glmS is active in the following subcellular-locations: cytoplasm.
GO terms: glmS is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project glmS has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For glmS there are:
11 structures (25 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


glmS has been screened with compounds ( bioactivities). (see details)