Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOQ (P17081) - Overview - Molecular Target Synopsis

Protein


RHOQ, Rho-related GTP-binding protein RhoQ
UniProt P17081

Also Known as RHOQ_HUMAN, RHOQ, ARHQ, RASL7A, TC10

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.

2ATX
CRYSTAL STRUCTURE OF THE TC10 GPPNHP COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RHOQ

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHOQ is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: RHOQ is active in the following subcellular-locations: actin filament, cell cortex, cell projection, cytoplasm, cytosol, extracellular exosome, Golgi-associated vesicle membrane, membrane raft, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOQ has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, MALME_3M, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-2, SK-MEL-28, HMY-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, AG445

(see details)

3D Structures


For RHOQ there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOQ has been screened with compounds ( bioactivities). (see details)