Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BicD (P16568) - Overview - Molecular Target Synopsis

Protein


BicD, Protein bicaudal D
UniProt P16568

Also Known as BICD_DROME, BicD

This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Interacts (via C-terminal domain) with Rab6.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
782P16568-1

Sub-cellular localization


UniProt: BicD is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: BicD is active in the following subcellular-locations: cytoplasm, cytoskeleton, cytosol, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BicD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For BicD there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis