Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

BicD (P16568) - Overview - Molecular Target Synopsis


BicD, Protein bicaudal D
UniProt P16568

Also Known as BICD_DROME, BicD

This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Interacts (via C-terminal domain) with Rab6.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: BicD is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: BicD is active in the following subcellular-locations: cytoplasm, cytoskeleton, cytosol, presynapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project BicD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures

For BicD there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis