Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PCSK2 (P16519) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JXG_A 51.77 0 1.8Å - 2016-10-05
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_E 52.22 0 2.6Å NAG 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HZD_A 51.77 0 1.9Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HZB_A 51.77 0 1.9Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 1R64_A 40.52 1.0E-93 2.2Å NAG 2004-03-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_B 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 1OT5_B 40.52 1.0E-93 2.4Å NAG 2003-06-17
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JXI_A 51.77 0 2Å - 2016-10-05
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_E 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_H 52.22 0 2.6Å NAG 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_A 52.22 0 2.6Å GAL NAG BMA FUL MAN 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_C 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HZC_A 51.77 0 1.9Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 2ID4_B 40.52 8.0E-94 1.9Å NDG 2007-05-01
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_A 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6EQX_A 51.77 0 1.99Å - 2018-02-28
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_A 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JMO_B 51.77 0 1.998Å NAG 2016-12-07
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HZA_A 51.77 0 1.9Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_D 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_E 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HLB_A 51.77 0 2Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_C 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HLD_A 51.77 0 2.1Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_D 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JMO_A 51.77 0 1.998Å NAG 2016-12-07
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_F 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 1R64_B 40.52 1.0E-93 2.2Å NAG BTB 2004-03-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5MIM_A 51.77 0 1.9Å 1N 2017-05-10
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JXH_A 51.77 0 2Å - 2016-10-05
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_B 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_F 52.22 0 2.6Å NAG 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 2ID4_A 40.52 8.0E-94 1.9Å MLA NDG 2007-05-01
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_C 52.22 0 2.6Å - 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (79%) (view alignment) KEX2 (P13134) - BAKER'S YEAST 1OT5_A 40.52 1.0E-93 2.4Å NAG 2003-06-17
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6EQV_A 51.77 0 1.89Å - 2018-02-28
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 5JXJ_A 51.77 0 2Å - 2016-10-05
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_D 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4Z2A_A 52.43 0 1.89Å - 2016-05-04
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_E 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_B 52.22 0 2.6Å NAG 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_A 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6EQW_A 51.77 0 1.99Å - 2018-02-28
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_C 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMC_F 51.77 0 2.3Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_G 52.22 0 2.6Å NAG BMA FUC 2003-07-08
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 6HLE_A 51.77 0 1.99Å - 2019-02-06
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4OMD_F 51.77 0 2.7Å - 2014-04-09
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) FURIN (P09958) - HUMAN 4RYD_B 51.77 0 2.15Å - 2015-05-27
Subtilase family (100%), Proprotein convertase P-domain (100%) (view alignment) Furin (P23188) - HOUSE MOUSE 1P8J_D 52.22 0 2.6Å - 2003-07-08