Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PCSK2 (P16519) - Overview - Molecular Target Synopsis

Protein


PCSK2, Neuroendocrine convertase 2
Enzyme Classification 3.4.21.94
UniProt P16519

Also Known as NEC2_HUMAN, PCSK2, NEC2

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PCSK2 is active in the following subcellular-locations: cytoplasmic vesicle, secreted, secretory vesicle.
GO terms: PCSK2 is active in the following subcellular-locations: dendrite, extracellular space, intracellular membrane-bounded organelle, membrane, neuron projection, nucleus, perikaryon, secretory granule, transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PCSK2 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2198, NCI-H209, A-673

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to PCSK2 there are:
21 structures (44 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PCSK2 has been screened with 7 compounds (7 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)