Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DPEP1 (P16444) - Overview - Molecular Target Synopsis

Protein


DPEP1, Dipeptidase 1
Enzyme Classification 3.4.13.19
UniProt P16444

Also Known as DPEP1_HUMAN, DPEP1, MDP, RDP

Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Homodimer; disulfide-linked.

1ITQ
HUMAN RENAL DIPEPTIDASE
RCSB/PDB
Inspect Structure
See all 3D Structures for DPEP1

Isoforms / Transcripts (Protein Coding)


Drugs


DPEP1 is targeted by Approved Drug Cilastatin. (see details)
Cilastatin

Sub-cellular localization


UniProt: DPEP1 is active in the following subcellular-locations: apical cell membrane, cell projection, microvillus membrane.
GO terms: DPEP1 is active in the following subcellular-locations: anchored component of membrane, apical part of cell, apical plasma membrane, cell junction, extracellular exosome, extracellular space, microvillus membrane, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DPEP1 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HCC_2998, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HM7, LS1034, HT-55

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For DPEP1 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DPEP1 has been screened with 68 compounds (68 bioactivities), 18 compounds have bioactivities that show binding affinity of <= 500nM (18 bioactivities). (see details)