Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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RPB3 (P16370) - Overview - Molecular Target Synopsis

Protein


RPB3, DNA-directed RNA polymerase II subunit RPB3
UniProt P16370

Also Known as RPB3_YEAST, RPB3

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination. Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

6O6C
RNA POLYMERASE II ELONGATION COMPLEX ARRESTED AT A CPD LESION
RCSB/PDB
Inspect Structure
See all 3D Structures for RPB3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
318P16370-1

Sub-cellular localization


UniProt: RPB3 is active in the following subcellular-locations: nucleus.
GO terms: RPB3 is active in the following subcellular-locations: nucleoplasm, RNA polymerase II.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPB3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RPB3 there are:
134 structures (136 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis