Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

adk (P16304) - Overview - Molecular Target Synopsis

Protein


adk, Adenylate kinase
Enzyme Classification 2.7.4.3
UniProt P16304

Also Known as KAD_BACSU, adk

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Monomer.

5X6I
CRYSTAL STRUCTURE OF B. SUBTILIS ADENYLATE KINASE VARIANT
RCSB/PDB
Inspect Structure
See all 3D Structures for adk

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
217P16304-1

Sub-cellular localization


UniProt: adk is active in the following subcellular-locations: cytoplasm.
GO terms: adk is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project adk has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For adk there are:
17 structures (28 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


adk has been screened with compounds ( bioactivities). (see details)