Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

PNLIP (P16233) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1GPL_A Pancreatic triacylglycerol lipase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 65.7 44.9 Yes No
2 empty 2.43 60.9 36.7 No No
3 empty 2.04 66.2 27.5 No No
4 empty 1.99 76.4 13.6 No No
5 empty 2.13 68.3 18.2 No No
6 empty 2.01 66.7 13.5 No No
7 empty 2.27 71.1 10.3 No No
8 empty 2.18 61.9 12.6 No No
9 empty 2.26 62.1 17.7 No No
10 empty 2.11 69.8 9.3 No No
1LPB_B Pancreatic triacylglycerol lipase No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 65.6 16.6 No No
2 bound 1.19 70.7 23.9 No No
3 bound 2.15 72.6 19.8 No No
4 empty 1.97 72.9 14.7 No No
5 empty 2 52.6 20.3 No No
6 empty 1.54 55.9 15.3 No No
7 empty 1.72 56.2 21.3 No No
8 empty 2.08 56.5 14.7 No No
9 empty 2.14 70.3 12.3 No No
10 empty 1.61 62.6 11.4 No No
1LPA_B Pancreatic triacylglycerol lipase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 72.2 21.5 Yes No
2 bound 1.25 69.8 27.5 No No
3 empty 2.13 67.2 21 No No
4 empty 1.85 65.3 17.4 No No
5 empty 2.18 63.8 21 No No
6 empty 2.11 63 24.3 No No
7 empty 2.01 60.5 18.8 No No
8 empty 1.98 60.3 18.6 No No
9 empty 2.42 67.8 18.5 No No
10 empty 1.96 66.3 17.5 No No
1N8S_A Pancreatic triacylglycerol lipase No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 67.4 18.8 No No
2 empty 1.57 62.3 22.6 No No
3 empty 2.1 67.1 22.1 No No
4 empty 1.96 65.7 26.8 No No
5 empty 2.3 61.8 24.5 No No
6 empty 2.24 73.2 15.9 No No
7 empty 2.21 69.7 14.7 No No
8 empty 2.34 69.5 14.5 No No
9 empty 2.07 61 20 No No
10 empty 2.05 71.9 18.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1GPL_A (23645) Pancreatic triacylglycerol lipase Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 2.01Å Yes No
1GPL_A (34793) Pancreatic triacylglycerol lipase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 2.01Å Yes No
1LPA_B (34792) Pancreatic triacylglycerol lipase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 3.04Å Yes No
1LPA_B (23644) Pancreatic triacylglycerol lipase Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 3.04Å No No
1LPB_B (23643) Pancreatic triacylglycerol lipase Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 2.46Å No No
1LPB_B (34791) Pancreatic triacylglycerol lipase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 2.46Å No No
1N8S_A (80308) Pancreatic triacylglycerol lipase Lipase/lipooxygenase domain (PLAT/LH2 domain), Lipase/lipooxygenase domain (PLAT/LH2 domain), Colipase-binding domain 3.04Å Yes No
1N8S_A (80309) Pancreatic triacylglycerol lipase alpha/beta-Hydrolases, alpha/beta-Hydrolases, Pancreatic lipase N-terminal domain 3.04Å No No
Ligand-based Druggability Score: -0.8
Ligand-based Druggability Score Percentile: 71%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PNLIP is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 88.94
Druggability for Cancer Therapeutics: 47.68
Druggability for Other Therapeutics: 96.97
Cancer-Associated
Cancer-associated percentile : 21.17
Network Articulation Point
Is PNLIP critical for communication in the network?


Detailed Graph Legend:Help