Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNLIP (P16233) - Overview - Molecular Target Synopsis

Protein


PNLIP, Pancreatic triacylglycerol lipase
Enzyme Classification 3.1.1.3
UniProt P16233

Also Known as LIPP_HUMAN, PNLIP


1N8S
STRUCTURE OF THE PANCREATIC LIPASE-COLIPASE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for PNLIP

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
465ENSG00000175535ENST00000369221ENSP00000358223P16233-1

Drugs


PNLIP is targeted by Approved Drug Orlistat. (see details)
Orlistat

Sub-cellular localization


UniProt: PNLIP is active in the following subcellular-locations: secreted.
GO terms: PNLIP is active in the following subcellular-locations: extracellular region, extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNLIP has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, CAKI_1, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PNLIP there are:
4 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNLIP has been screened with 80 compounds (111 bioactivities). (see details)