Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NPR1 (P16066) - Overview - Molecular Target Synopsis

Protein


NPR1, Atrial natriuretic peptide receptor 1
Enzyme Classification 4.6.1.2
UniProt P16066

Also Known as ANPRA_HUMAN, NPR1, ANPRA

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1061ENSG00000169418ENST00000368680ENSP00000357669P16066-1

Sub-cellular localization


UniProt: NPR1 is active in the following subcellular-locations: membrane.
GO terms: NPR1 is active in the following subcellular-locations: integral component of membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NPR1 has gain in 16 cell-lines, loss in 0 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, TK_10, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, COV413A, NCI-H2795

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HUVEC, SK-N-SH

(see details)

3D Structures


At greater than 75% identity similarity to NPR1 there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NPR1 has been screened with 168 compounds (181 bioactivities), 61 compounds have bioactivities that show binding affinity of <= 500nM (61 bioactivities). (see details)